Depending on the administrators' settings, yes, you can end a relationship with a mentor and pick a new relationship (or not continue any relationships). Once the relationship ends, any potential matches will appear in the mentee portal, if you are allowed to match yourself with a new mentor.
To end a relationship, click 'End Relationship' on your user dashboard. Another way is to go to the 'My Mentoring Connections' tab then choose 'My Connection'. From here you can select 'End Relationship'. If the setting is unavailable, please contact your portal administrator.